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A Brief Introduction of Dihydromyricetin!

What is Dihydromyricetin?
MSDS of Dihydromyricetin
Source of Dihydromyricetin
Solubility of Dihydromyricetin
Stability of Dihydromyricetin
HS Code of Dihydromyricetin
Function of Dihydromyricetin
Dihydromyricetin in Medical History
Research Articles of Dihydromyricetin
Recommended Dihydromyricetin Dosage

Dihydromyricetin supplier – ALB Technology Limited.

 

What is Dihydromyricetin?
Dihydromyricetin, also known as Ampelopsin, is a type of flavonoid, a natural antioxidant, which can be extracted from the plant Ampelopsis grossedentata. Ampelopsis grossedentata, or Vine Tea, is called Teng Cha in China, as a Chinese Herbal Medicine it can alleviate fevers, drunkenness, cure rheumatism, strengthen physique, diuresis, and also shows many other functions.
Synonyms: Ampelopsin, DHM, DMY, Hovenia dulcis Extract, Vine Tea Extract, CAS#27200-12-0, (+)-Ampelopsin, (+)-Dihydromyricetin

Identification of Dihydromyricetin:
Name: Dihydromyricetin
IUPAC Name: (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
CAS Number: 27200-12-0
Molecular Formula: C15H12O8
Molecular Weight: 320.25
Structure of Dihydromyricetin:
Dihydromyricetin Structure

 

MSDS of Dihydromyricetin
MSDS of Dihydromyricetin.pdf

 

Source of Dihydromyricetin
Dihydromyricetin (DHM) can be found in Ampelopsis Grossedentata (Snake Wine Vine, also called Vine Tea or Teng Cha in China), Japanese Raisin Tree (Hovenia Dulcis), the Himilayan Cedar Tree (Cedrus Deodara) or the African Blackwood (Erythrophleum Africanum).

Commercial available Dihydromyricetin (DHM) source are mostly from Ampelopsis Grossedentata or Hovenia Dulcis.

Snake Wine Vine (Ampelopsis Grossedentata, also called Vine Tea or Teng Cha in China) grows in the warm climates of China. The stems and leaves of the vine have traditionally been used in treating the common cold, fever, swelling of the pharynx and larynx, cough relief, and improving liver health. Stems and leaves of Ampelopsis Grossedentata contain about 40% Dihydromyricetin.

Hovenia Dulcis can be found naturally in the areas surrounding China and has a long history of medical use in Asia. It is one of the earliest documented plants used in traditional Chinese medicine; the fruits and stems of Hovenia Dulcis have been medicinally for centuries.

 

Solubility of Dihydromyricetin
Dihydromyricetin (DHM), as a substance, is easy soluble in hot water.
1.60g DHM/100mL water at 100 ℃
0.07g DHM/100mL water at 25℃
It is soluble in ethanol, acetone or methanol - hot or cold.
Dihydromyricetin is slightly soluble in acetic ether, and is completely insoluble in chloroform and petroleum ether.
Dihydromyricetin (DHM) is soluble in DMSO to 100 mM and in ethanol to 100 mM.

 

Stability of Dihydromyricetin
Dihydromyricetin (DHM) is stable in heat, but when heated to 100℃ or above, it is irreversibly oxidized. The substance is stable in acidity and neutral.

 

HS Code of Dihydromyricetin
The HS Code (Harmonization System Code) of Dihydromyricetin is 2932999099.

 

Function of Dihydromyricetin
Research shows Dihydromyricetin have below function:
1. Prevent Hangovers, Protecting the Liver, protect your liver from alcohol toxicity
2. Clearing the free radical in body and antioxidation
3. Antibiotic Action
4. Reducing the levels of blood sugar and blood fat
5. Anti-inflammation
6. Anti-tumor

 

Dihydromyricetin in Medical History
Uses of Ampelopsis Grossedentata or Hovenia Dulcis can be found in ancient medical texts, such as the Compendium of Materia Medica and Materia Medica of Tang. These texts record the use of Hovenia Dulcis for detoxification and recovery from alcohol poisoning and treatment and recovery from liver damage.

While it has been known for centuries that all of these plants provide health benefits, the mechanism of those benefits has only recently been discovered. Recent research has shown that the health benefits of these plants can largely be attributed to their high concentrations of Dihydromyricetin.

Leaves of Ampelopsis Grossedentata contain about 40% Dihydromyricetin.

 

Research Articles of Dihydromyricetin
1. Dihydromyricetin as a novel anti-alcohol intoxication medication.
Shen Y1, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J.

2. Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence.
Liang J1, Shen Y, Shao XM, Scott MB, Ly E, Wong S, Nguyen A, Tan K, Kwon B, Olsen RW, Spigelman I.

3. Dihydromyricetin improves physical performance under simulated high altitude.
Zou D1, Chen K, Liu P, Chang H, Zhu J, Mi M.

4. Effect of dihydromyricetin on benzo[a]pyrene activation in rats.
Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.

5. Dihydromyricetin ameliorates behavioral deficits and reverses neuropathology of transgenic mouse models of Alzheimer's disease.
Liang J1, López-Valdés HE, Martínez-Coria H, Lindemeyer AK, Shen Y, Shao XM, Olsen RW.

6. Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin.
Zhu H1, Luo P1, Fu Y1, Wang J1, Dai J1, Shao J1, Yang X1, Chang L1, Weng Q1, Yang B1, He Q1.

7. Dihydromyricetin induces apoptosis and inhibits proliferation in hepatocellular carcinoma cells.
Liu J1, Shu Y1, Zhang Q1, Liu B1, Xia J1, Qiu M2, Miao H1, Li M1, Zhu R1.

8. Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata.
Zhang YS1, Ning ZX, Yang SZ, Wu H.

9. Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways.
Hou X1, Tong Q1, Wang W1, Xiong W1, Shi C1, Fang J2.

10. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders.
Davies DL et al. Alcohol Clin Exp Res. (2013)

 

Recommended Dihydromyricetin Dosage

As Dihydromyricetin (DHM) is still a relatively new herbal drug, it’s dosages have only really been tested on rats and mice. An alcohol extract of 125mg max per kg of bodyweight has been used in rats with efficacy, which translates to an estimated human dosage of 9-9.3mg per lbs human weight, equals to:

1,400mg for a 150lb person
1,800mg for a 200lb person
2,300mg for a 250lb person

This is an estimated human maximum doses based on rat studies.

The typical commercial dose of Dihydromyricetin is 300 mg per capsule. It is suggested to take 1 - 2 capsules for a total of 600 mg, to counteract the effects of up to 6 servings of hard liquor. This dosage can produce sobering effects if taken immediately after drinking. Most people take a dosage to prevent the following day’s hangover.

 

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